Collaborative Opportunities for Multiple-disciplinary, Bold, and Integrated Endeavors (COMBINE) (RM1 Clinical Trial Optional)

HHS-NIH11 Forecasted PAR-27-066

Description

The Collaborative Opportunities for Multiple-disciplinary, Bold, and Integrated Endeavors (COMBINE) program supports the pursuit of a single focused problem that, when solved, will overcome persistent barriers, challenge orthodoxies, achieve paradigm-shifts, or develop new foundational scientific principles. Highly integrated transdisciplinary teams led by 3-6 PDs/PIs are expected to deliver defined outcomes within the funding period that advance the mission of the participating ICs and transform knowledge or practice, ranging from fundamental biomedical science to human health. The proposed problem must be of sufficient scope and complexity to require an innovative convergence of disciplines, expertise, and approaches that will not be feasible through the structure of traditional R01 or Program Project/Center grant mechanisms.

Eligibility

Other Eligible ApplicantsIndian/Native American Tribal Governments (Other than Federally Recognized);Eligible Agencies of the Federal Government;U.S. Territory or Possession;Faith-based or Community-based Organizations;Regional Organizations;Non-domestic (non-U.S.) Entities (Foreign Institutions).
Funding Details
Award Floor
Not specified
Award Ceiling
Not specified
Total Estimated Funding
Not specified
Expected Awards
Not specified
Key Dates
Posted
August 28, 2025
Closes
N/A
Archive Date
August 19, 2026
Agency Information
Agency Name
National Institutes of Health
Agency Code
HHS-NIH11
Funding Instrument
Other